Answer
An endocrine cell secretes a hormone into the extracellular fluid, where it enters the bloodstream for systemic circulation. While water-soluble hormones dissolve directly in plasma, water-insoluble (lipid-soluble) hormones must bind to transport proteins to be carried through the blood. At the target tissue, the hormone exits circulation and selectively binds to a specific receptor on the target cell's surface or within its interior. This receptor activation triggers a cellular response, which typically includes: (1) altering the rates of enzyme-catalyzed reactions, (2) modifying the movement of ions or molecules across the plasma membrane, or (3) regulating gene expression and protein synthesis.
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