OBSintermediate

Order the stages of Plasmodium infection in the human host chronologically, beginning immediately after the bite of an infected female Anopheles mosquito.

Answer

Sporozoites are injected into the bloodstream during the mosquito bite, Sporozoites migrate through circulation and invade liver hepatocytes, Merozoites are released into the bloodstream following hepatic schizogony, Merozoites invade erythrocytes to begin the asexual erythrocytic cycle

Explanation

The mosquito inoculates sporozoites, which briefly circulate before entering liver cells. Liver multiplication releases merozoites into blood, where red-cell infection begins the asexual erythrocytic cycle. **Key takeaway:** The liver stage precedes symptomatic blood-stage multiplication.\n\n**Glossary:** **Sporozoite**: mosquito-inoculated parasite stage; **merozoite**: stage that invades red blood cells; **schizogony**: asexual multiplication.

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