In the context of malaria chemotherapy and treatment outcomes, define each of the following five terms: cure, recurrence, recrudescence, relapse, and drug resistance.
Answer
- Cure: Complete elimination of clinical symptoms and causative asexual blood-stage parasites. - Recurrence: Reappearance of asexual parasitaemia after treatment, which may be caused by recrudescence, relapse, or reinfection. - Recrudescence: Reappearance of asexual parasitaemia resulting from the survival of blood-stage parasites following treatment. - Relapse: Reappearance of asexual parasitaemia resulting from the reactivation of dormant liver hypnozoites in Plasmodium vivax or Plasmodium ovale infections. - Drug resistance: The ability of a parasite strain to survive or multiply despite the administration and absorption of an antimalarial drug given in doses equal to or higher than typically recommended.
Explanation
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