Paedintermediate
Match each step in the pathogenesis of tetanus to its corresponding description: Steps: - Spore germination - Retrograde axonal transport - Tetanospasmin action - Reduced neural inhibition Descriptions: - Occurs in an anaerobic, devitalized wound environment - Toxin travels along motor neurons to spinal inhibitory interneurons - Blocks the release of inhibitory neurotransmitters (GABA and glycine) - Produces sustained motor neuron firing leading to spastic paralysis
Answer
Spore germination - Occurs in an anaerobic, devitalized wound environment; Retrograde axonal transport - Toxin travels along motor neurons to spinal inhibitory interneurons; Tetanospasmin action - Blocks the release of inhibitory neurotransmitters (GABA and glycine); Reduced neural inhibition - Produces sustained motor neuron firing leading to spastic paralysis
Explanation
These matches follow the mechanism presented in the slides, from local germination to toxin action and clinical effect. They also distinguish toxin transport from toxin's effect on neurotransmission. **Key takeaway:** The sequence connects wound conditions to nervous-system disinhibition and spasms.\n\n**Glossary:** **Disinhibition**: increased activity resulting from loss of inhibitory control.
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