High-velocity turbulent blood flow across a cardiac defect causes endocardial injury, predisposing to infective endocarditis. Which of the following lesions is most likely to generate this high-velocity jet and increased risk?
Answer
Ventricular septal defect
Explanation
The lecture highlights congenital lesions with high-velocity turbulent flow, including VSD, as risk settings for endocardial injury and IE. **Key takeaway:** The hemodynamic effect of a lesion matters to risk. **Glossary:** VSD: ventricular septal defect.