OBSadvanced
Explain how placental sequestration of infected erythrocytes can affect fetal growth.
Answer
In pregnancy-associated malaria, infected erythrocytes adhere to chondroitin sulfate A on the syncytiotrophoblast lining the intervillous space. The resulting inflammatory response can thicken the placenta and impair oxygen and nutrient transfer, contributing to fetal growth restriction and possibly fetal demise.
Explanation
The material describes parasite sequestration in the placental intervillous space, mediated by pregnancy-associated variant surface antigens binding to **chondroitin sulfate A (CSA)**. Inflammation and placental thickening may compromise transport to the fetus. **Key takeaway:** Placental infection can harm fetal development even when maternal symptoms are limited.\n\n**Glossary:** **Sequestration**: trapping or accumulation of infected cells in tissue; **syncytiotrophoblast**: the placental cell layer exposed to maternal blood; **IUGR**: intrauterine growth restriction.
Related Questions
- Explain why correct placement at the vacuum flexion point matters and describe where that point is located.(advanced)
- The forceps specially designed to deliver the after-coming head in breech birth are _____ forceps.(basic)
- For forceps delivery, the fetal head should be engaged and the position of the vertex known with certainty.(basic)
- Which of the following is a mandatory prerequisite before proceeding with a forceps-assisted vaginal delivery?(intermediate)
- Arrange these principal stages of vacuum extraction in order.(intermediate)
Want to practice more questions like this?
Join myBenkio free and practice past questions for your Nigerian university courses with AI explanations for every answer.
Start Practicing Free