Native and prosthetic heart valves are frequent sites of IE.
Answer
true
Explanation
The lecture identifies native and prosthetic valves as the most frequently involved sites. Septal defects, mural endocardium, and implanted devices can also be affected. **Key takeaway:** Valve status and cardiac devices are important risk considerations. **Glossary:** Prosthetic: artificially implanted to replace or support a body structure.