Pediatricsintermediate
Match each pathogenic mechanism or lesion of infective endocarditis with its characteristic clinical manifestation: 1. Aortic or mitral valve destruction 2. Left-sided systemic embolization 3. Right-sided vegetations (e.g., tricuspid valve) 4. Circulating immune-complex deposition Manifestations: - Ischemic stroke or cerebral abscess - Glomerulonephritis - Acute heart failure - Septic pulmonary emboli
Answer
Aortic or mitral valve destruction - Acute heart failure; Left-sided systemic embolization - Ischemic stroke or cerebral abscess; Right-sided vegetations (e.g., tricuspid valve) - Septic pulmonary emboli; Circulating immune-complex deposition - Glomerulonephritis
Explanation
These pairings connect cardiac lesions, embolic spread, and immune phenomena to their complications. **Key takeaway:** IE can injure organs through mechanical, embolic, and immune-mediated mechanisms. **Glossary:** Immune complex: an antigen-antibody aggregate that can deposit in tissues.
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