What is the immediate neurotransmitter effect described for tetanospasmin?

Tetanospasmin inhibits the inhibitory neurotransmitters GABA and glycine. The resulting loss of inhibitory control exaggerates excitatory stimulation, producing rigidity and spasms. It is not described as an insulin effect, red-cell effect, or blockade of all excitation. **Key takeaway:** Tetanus spasms result from diminished inhibition, not simply generalized muscle damage.\n\n**Glossary:** **Excitatory**: tending to increase activity in a target cell.