Pediatricsbasic
What is the hallmark mechanism described for ARF pathogenesis?
Answer
Molecular mimicry
Explanation
**Molecular mimicry** occurs when immune recognition of GAS antigens cross-reacts with similar human structures. The lecture identifies it as the hallmark of ARF pathogenesis. **Key takeaway:** ARF is an immune-mediated consequence of infection, not simply bacterial growth in the heart. **Glossary:** Antigen: a molecule recognized by the immune system.
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