Pediatricsadvanced
Which statement about doxorubicin-associated cardiotoxicity is most accurate according to the slides?
Answer
It most often causes chronic, dose-dependent DCM that may appear months or years later.
Explanation
Doxorubicin may cause acute myocarditis during administration, but the more common manifestation described is **severe, chronic, dose-dependent cardiomyopathy**. It can become evident months or years after treatment. Acute myocarditis is often reversible and has a better long-term prognosis than chronic symptomatic disease. **Key takeaway:** Doxorubicin toxicity may be delayed, so past exposure remains clinically relevant.\n\n**Glossary:** **Dose-dependent**: The risk or severity changes with the amount of exposure. **Cardiotoxicity**: Harmful effect on the heart.
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