Paedintermediate
Describe the demographic groups at highest risk for tetanus worldwide and identify the primary immunological factor that determines susceptibility to the disease.
Answer
Newborns (neonatal tetanus) and young individuals in developing countries are at the highest risk, with susceptibility primarily determined by lack of immunization or waning immunity due to missing booster doses.
Explanation
A strong answer includes the broad age range, higher prevalence noted among newborns and young persons, association with developing countries and environmental conditions, and the role of absent or waning immunity. The material reports no undue sex predilection. **Key takeaway:** Tetanus risk reflects immunization status and exposure as well as population and environmental context.\n\n**Glossary:** **Waning immunity**: declining protection over time; **sex predilection**: a marked difference in occurrence between sexes.
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