Gamma globulins are the exception to the general rule that most plasma proteins are synthesized in the liver.

### Why this is right Most plasma proteins are made in the liver, but gamma globulins, which include antibodies, are produced by immune cells. This makes them a major exception to the general rule. ### The concept Plasma proteins have varied roles, including transport, clotting, immune defense, acid-base regulation, and maintenance of oncotic pressure. Their functions and sources are not identical. ### Terms - **Gamma globulin**: a class of blood proteins that includes antibodies. - **Antibody**: an immune protein that recognizes a particular target. ### Remember Most plasma proteins come from the liver; antibodies are made by immune cells.