Which is the most significant complication of ARF?
Answer
Rheumatic heart disease
Explanation
**RHD** is the major long-term complication and accounts for much of ARF's cardiovascular morbidity and mortality. Arthritis and chorea usually resolve without sequelae. **Key takeaway:** Cardiac injury, rather than joint or neurologic symptoms, drives long-term burden. **Glossary:** Sequela: a lasting consequence of disease.