Which is the most significant complication of ARF?

Answer

Rheumatic heart disease

Explanation

**RHD** is the major long-term complication and accounts for much of ARF's cardiovascular morbidity and mortality. Arthritis and chorea usually resolve without sequelae. **Key takeaway:** Cardiac injury, rather than joint or neurologic symptoms, drives long-term burden. **Glossary:** Sequela: a lasting consequence of disease.

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