Pediatricsbasic
What is the genetic basis described for primary familial HCM?
Answer
Mutations in genes encoding sarcomere proteins
Explanation
Primary familial HCM is attributed to mutations in genes encoding **protein components of the sarcomere**. The sarcomere is the contractile unit of muscle, making this a genetic myocardial disease. The other options are not the mechanism stated in the material. **Key takeaway:** Familial HCM is linked to mutations affecting cardiac muscle contractile proteins.\n\n**Glossary:** **Sarcomere**: The basic contractile unit of striated muscle.
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