Pediatricsintermediate
Arrange the stages in the pathogenesis of rheumatic heart disease in chronological order, from the initial inciting event to the chronic sequela.
Answer
Group A streptococcal pharyngitis, Cross-reactive immune response against cardiac antigens via molecular mimicry, Acute immune-mediated cardiac inflammation, Chronic valvular fibrosis and deformity
Explanation
GAS infection precedes the cross-reactive immune response, which can inflame cardiac tissues. Healing and repeated injury may leave fibrotic, deformed valves. **Key takeaway:** Chronic RHD can arise from recurrent immune-mediated injury. **Glossary:** Valvular deformity: structural change affecting valve opening or closure.
Related Questions
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- After a prior episode of ARF, recurrence following untreated GAS pharyngitis can approach 50%.(intermediate)
- The highest incidence of ARF occurs in children aged approximately _____ years.(basic)
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