The pericardium anchors the heart in the central thorax and can act as a barrier to infection.

This statement is **true**. The pericardium attaches to structures including the sternum and diaphragm and surrounds the great vessels and vena cavae, helping hold the heart in its central thoracic position. The lecture also identifies a barrier function against infection. These roles are distinct from the pericardium's capacity to become inflamed or to restrict cardiac filling when diseased. **Key takeaway:** The pericardium has both supportive and protective functions. **Glossary:** **Thorax**: the chest cavity. **Vena cavae**: the major veins returning blood to the heart.