Match each level of protein structure with its defining characteristic: 1. Primary structure 2. Secondary structure 3. Tertiary structure 4. Quaternary structure A. Linear sequence of amino acids linked by peptide bonds B. Regular, repeating local conformations such as alpha helices and beta sheets C. Overall three-dimensional folding of a single polypeptide chain D. Spatial organization and assembly of two or more polypeptide subunits

Answer

1-A, 2-B, 3-C, 4-D

Explanation

Protein structure is organized hierarchically. The amino-acid sequence is primary structure; local repeating elements are secondary; the overall fold of one chain is tertiary; and the association of two or more chains is quaternary. **Key takeaway:** Each structural level describes a different scale of organization. **Glossary:** Subunit: an individual polypeptide in a multisubunit protein.

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