Arrange these pain-processing events from initial detection to possible brain-based modulation.

### The order 1. **Nociceptors detect a noxious stimulus**: Detection is the starting point of nociception. 2. **Pain signals travel through the spinal cord along ascending pathways**: Signals are transmitted toward the brain. 3. **Brain regions interpret signals and contribute to pain perception**: Processing in several regions helps create the subjective experience. 4. **Descending pathways influence pain intensity and perception**: The brain can then modulate pain through descending influence. ### The concept This sequence separates initial sensory detection from transmission and interpretation. Descending modulation is an influence from the brain that can change pain processing rather than another ascending transmission step. ### Terms - **Nociceptor**: A sensory neuron that detects noxious stimuli. - **Ascending pathway**: A pathway carrying signals toward the brain. - **Descending pathway**: A pathway carrying brain influence toward lower neural structures. ### Remember Pain processing moves from detection to ascending transmission and brain interpretation, with descending modulation able to alter the experience.