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Which enzyme cleaves fructose-1-phosphate into glyceraldehyde and dihydroxyacetone phosphate?

Answer

Aldolase B

Explanation

### Why this is right In the liver fructose pathway, fructokinase forms fructose-1-phosphate, and aldolase B cleaves it into glyceraldehyde and dihydroxyacetone phosphate. These products can enter intermediary metabolism. ### The concept Fructose can also be phosphorylated by hexokinase to fructose-6-phosphate, which enters glycolysis by a different route. Aldolase B is specifically associated with the fructose-1-phosphate pathway. ### The other options - **Galactokinase**: Phosphorylates galactose, not fructose-1-phosphate. - **Hexokinase**: Can form fructose-6-phosphate from fructose but does not cleave fructose-1-phosphate. - **Lactase**: Hydrolyzes lactose into glucose and galactose. ### Terms - **Dihydroxyacetone phosphate**: A three-carbon glycolytic intermediate. - **Aldolase B**: The enzyme that cleaves fructose-1-phosphate in liver fructose metabolism. ### Remember Aldolase B deficiency is associated with hereditary fructose intolerance.

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