Bchintermediate
Which enzyme bypasses the phosphofructokinase reaction during gluconeogenesis?
Answer
Fructose-1,6-bisphosphatase
Explanation
### Why this is right
Fructose-1,6-bisphosphatase hydrolyzes fructose-1,6-bisphosphate to fructose-6-phosphate. This bypasses the irreversible phosphofructokinase step of glycolysis.
### The concept
Gluconeogenesis uses different enzymes to bypass irreversible glycolytic reactions. It is therefore not simply glycolysis running backward.
### The other options
- **Phosphoglycerate mutase**: Catalyzes a reversible phosphate shift in glycolysis and gluconeogenesis.
- **Aldolase**: Reversibly interconverts fructose-1,6-bisphosphate and triose phosphates.
- **Triose phosphate isomerase**: Interconverts two triose phosphates.
### Terms
- **Gluconeogenesis**: Formation of glucose from non-carbohydrate precursors.
- **Phosphofructokinase**: The glycolytic enzyme that phosphorylates fructose-6-phosphate.
### Remember
Fructose-1,6-bisphosphatase bypasses phosphofructokinase.
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