Bchbasic
Pompe disease is caused by deficiency of lysosomal alpha-1,4-glucosidase, also called acid maltase.
Answer
true
Explanation
### Why this is right
Pompe disease is caused by deficiency of lysosomal alpha-1,4-glucosidase. The enzyme normally degrades glycogen within lysosomes, so its deficiency causes glycogen accumulation there.
### The concept
This disorder differs from defects in cytoplasmic glycogen breakdown, such as muscle phosphorylase deficiency. The location of the enzyme defect helps distinguish the metabolic disorder.
### Terms
- **Lysosome**: A cellular compartment that contains degradative enzymes.
- **Acid maltase**: Another name for lysosomal alpha-1,4-glucosidase.
### Remember
Pompe disease is the lysosomal glycogen degradation defect.
Related Questions
- Which enzyme deficiency can cause hemolysis after exposure to certain drugs because red blood cells cannot generate adequate reducing power?(advanced)
- Under anaerobic conditions, lactate dehydrogenase uses reduced nicotinamide adenine dinucleotide (NADH) to reduce pyruvate and regenerate nicotinamide adenine dinucleotide (NAD+).(basic)
- Where do the enzymes of glycolysis operate, and what is its principal end product under anaerobic conditions?(basic)
- Which enzyme cleaves fructose-1-phosphate into glyceraldehyde and dihydroxyacetone phosphate?(basic)
- Select ALL correct enzyme-product pairs in dietary carbohydrate digestion.(basic)
Want to practise more questions like this?
Join myBenkio free and practise past questions for your Nigerian university courses with AI explanations for every answer.
Start Practising Free